Embryo-endometrial interaction.

نویسندگان

  • Carlos Simón Valles
  • Francisco Domínguez
چکیده

Embryonic implantation, the process by which the human embryo orientates towards, attaches to and finally invades the underlying maternal endometrial tissue, requires a receptive endometrium, a functionally normal blastocyst and an adequate cross-communication between them. During apposition, human blastocysts find a location in which to implant, while they are guided to a specific area in the maternal endometrium. In the adhesion phase, which occurs 6 to 7 days after ovulation, within the so-called "implantation window", direct contact occurs between the endometrial epithelium (EE) and the trophectoderm (TE). Finally, in the invasion phase, the embryonic trophoblast traverses the basement membrane and passes the endometrial stroma and reaches the uterine vessels. Many molecules (hormones, cytokines, integrins, enzymes, etc.) take part in the dialogue between the human blastocyst and the maternal endometrium to achieve implantation. Here, we present our published data on the embryonic regulation of endometrial epithelial molecules such as chemokine receptors and the leptin system.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

I-40: Implantation Failure

Background: The process of implantation involves the interaction of the human embryo and the uterine epithelium. Failure of implantation is a major reason for infertility in women and the inability to achieve endometrial receptivity is responsible for much of the failure of reproductive technologies. Management of repeated implantation failure despite transfer of good-quality embryos still rema...

متن کامل

Biomarkers Related to Endometrial Receptivity and Implantation

Implantation is a process requiring the delicate interaction between the embryo and a receptive endometrium. This intricate interaction requires a harmonized dialogue between embryonic and maternal tissues. [Aghajanova et al., 2008; Simon et al., 2000] The three stages of implantation are: apposition, adhesion, and invasion. Apposition describes trophoblast cells adhering to the receptive endom...

متن کامل

P-191: A Comparison of The Effects of Transdermal Estradiol and Estradiol Valerate on Endometrial Receptivity in Frozen-Thawed Embryo Transfer Cycles: A Randomized Clinical Trial

Background: The aim of this prospective randomized clinical trial was to determine the optimal endometrial preparation protocol by comparing the clinical outcome of two methods of endometrial preparation in FET cycles, that is, oral estradiol and 17 β-estradiol transdermal patch. Materials and Methods: A total number of 90 patients were scheduled for FET. In the study group (n=45), 17-B estradi...

متن کامل

Effect of adding human chorionic gonadotropin to frozen thawed embryo transfer cycles with history of thin endometrium

BACKGROUND Embryo implantation process is a complex phenomenon and depends on fetal and maternal factors interaction. Endometrial thickness is needed for successful implantation. OBJECTIVE We designed this study in order to assess adding human chorionic gonadotropin (HCG) to the conventional protocol in endometrial preparation in women with thin endometrium and a history of in vitro fertiliza...

متن کامل

I-27: Different Regimens for Endometrial Preparationl

Freezed embryo transfer increases the cumulative pregnancy rate, reduces costs, is relatively simple to undertake and can be accomplished in a shorter time period compared to repeated Fresh cycle. There are different protocols for endometrial preparation. Although frozen embryo replacement cycles, have been used for several years, there is no agreement about the optimal way to prepare the endom...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Chang Gung medical journal

دوره 29 1  شماره 

صفحات  -

تاریخ انتشار 2006